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第12回分子脳科学セミナー (2022年12月22日熊本大学医学部図書棟4階第3講義室)

Induced juvenile-like plasticity (iPlasticity) by pharmacological and optogenetic manipulations

Juzoh Umemori

Gene and Cell technology, A.I.Virtanen Institute, University of Eastern Finland, Kuopio,

Finland, Neuroscience Center, HiLIFE, University of Helsinki, Helsinki, Finland.


We have demonstrated that antidepressants reopen or induce a critical period-like plasticity

(iPlasticity), which allows brain networks to better adapt to environmental stimuli, such as

training or rehabilitation, and consequently ameliorate neuropsychiatric symptoms. It is also

known that Brain-derived neurotrophic factor (BDNF), and its receptor tyrosine kinase TrkB

have pivotal roles in iPlasticity. We have developed an optically activatable TrkB receptor

(optoTrkB) and demonstrated that optoTrkB activation in Parvalbumin-positive interneurons

of the visual cortex and pyramidal neurons in the dorsal hippocampus induced behavioral

changes, shift of ocular dominance plasticity and promoted fear erasure, respectively

(Winkel et al., Mol Psychiatry, 2021; Umemori et al., BioRxiv, 2021). Recently, I started to

work at the University of Eastern Finland as an independent researcher, and attempt to

ameliorate symptoms of animal models of Alzheimer’s disease by manipulating TrkB activity

and reverse epigenomics on causative genes. I will introduce our iPlasticity studies and

discuss our future plans.

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