文東美紀 博士 (医学)

  • 1994年 日本大学農獣医学部応用生物科学科卒業

  • 1996年 東京大学大学院医学系研究科国際保健学専攻修士課程修了

  • 2000年 東京大学大学院医学系研究科分子細胞生物学専攻博士課程修了

  • 2000年~2001年 東京大学大学院医学系研究科 日本学術振興会特別研究員

  • 2001年~2002年 東京大学大学院医学系研究科 客員研究員

  • 2002年~2010年 理化学研究所脳科学総合研究センターテクニカルスタッフ

  • 2010年~2016年 東京大学大学院医学系研究科分子精神医学講座特任助教

  • 2010年~現在 理化学研究所脳科学総合研究センター客員研究員

  • 2016年~現在 科学技術振興機構さきがけ研究員(兼業)

  • 2016年~現在 熊本大学大学院生命科学研究部分子脳科学分野准教授

原著論文

  1. Nishioka M, Bundo M, Ueda J, Yoshikawa A, Nishimura F, Sasaki T, Kakiuchi C, Kato T, Iwamoto K. Identification of somatic mutations in monozygotic twins discordant for psychiatric disorders.
    npj Schizophrenia, in press

  2. Miura I*, Kunii Y, Hino M, Hoshino H, Matsumoto K, Kanno-Nozaki K, Horikoshi S, Kaneko H, Bundo M, Iwamoto K, Yabe H.
    DNA methylation of ANKK1 and response to aripiprazole in patients with acute schizophrenia: A preliminary study.
    Journal of Psychiatric Research, 100:84-87, 2018

  3. Sugawara H, Murata Y, Ikegame T, Sawamura R, Shimanaga S, Takeoka Y, Saito T, Ikeda M, Yoshikawa A, Nishimura F, Kawamura Y, Kakiuchi C, Sasaki T, Iwata N, Hashimoto M, Kasai K, Kato T, Bundo M*, Iwamoto K*.DNA methylation analyses of the candidate genes identified by a methylome-wide association study revealed common epigenetic alterations in schizophrenia and bipolar disorder.Psychiatry and Clinical Neurosciences, in press

  4. Murata Y, Bundo M*, Sunaga F, Kasai K, Iwamoto K*. DNA methylation profiling in a neuroblastoma cell line exposed to the antipsychotic perospirone. Pharmacopsychiatry, in press

  5. Shimada-Sugimoto M, Otowa T*, Miyagawa T, Umekage T, Kawamura Y, Bundo M, Iwamoto K, Ikegame T, Tochigi M, Kasai K, Kaiya H, Tanii H, Okazaki Y, Tokunaga K, Sasaki T. An epigenome-wide methylation study of healthy individuals with or without depressive symptoms. Journal of Human Genetics​, in press

  6. Nishioka M, Bundo M, Ueda J, Katsuoka F, Sato Y, Kuroki Y, Ishii T, Ukai W, Murayama S, Hashimoto E, Nagasaki M, Yasuda J, Kasai K, Kato T, Iwamoto K. Identification of somatic mutations in postmortem human brains by whole genome sequencing and their implications for psychiatric disorders. Psychiatry and Clinical Neurosciences, in press

  7. Murata Y, Bundo M, Ueda J, Kubota-Sakashita M, Kasai K, Kato T, Iwamoto K. DNA methylation and hydroxymethylation analyses of the active LINE-1 subfamilies in mice. Scientific Reports, 7, 13624, 2017

  8. Maekawa M, Watanabe A, Iwayama Y, Kimura T, Hamazaki K, Balan S, Ohba H, Hisano Y, Nozaki Y, Ohnishi T, Toyoshima M, Shimamoto C, Iwamoto K, Bundo M, Osumi N, Takahashi E, Takashima A, Yoshikawa T. Polyunsaturated fatty acid deficiency during neurodevelopment in mice models the prodromal state of schizophrenia through epigenetic changes in nuclear receptor genes. Translational Psychiatry, 7, e1229, 2017

  9. Ueda J†, Murata Y†, Bundo M, Oh-Nishi A, Kassai H, Ikegame T, Zhao Z, Jinde S, Aiba A, Suhara T, Kasai K, Kato T, Iwamoto K. († equal contribution) Use of human methylation arrays for epigenome research in the common marmoset (Callithrix jacchus). Neuroscience Research, 120:60-65, 2017

  10. Shimada-Sugimoto M, Otowa T, Miyagawa T, Umekage T, Kawamura Y, Bundo M, Iwamoto K, Tochigi M, Kasai K, Kaiya H, Tanii H, Okazaki Y, Tokunaga K, Sasaki T. Epigenome-wide association study of DNA methylation in panic disorder. Clinical Epigenetics, 9:6, 2017

  11. Yang W, Tanaka Y, Bundo M, Hirokawa N*. Antioxidant signaling involving the microtubule motor KIF12 is an intracellular target of nutrition excess in beta cells. Developmental Cell 2014,31:202-214.

  12. Sugawara H, Bundo M, Asai T, Sunaga F, Ueda J, Ishigooka J, Kasai K, Kato T, Iwamoto K*. Effects of quetiapine on DNA methylation in neuroblastoma cells. Progress in Neuro-Psychopharmacology and Biological Psychiatry 2014,56C:117-121.

  13. Koike S, Bundo M, Iwamoto K, Suga M, Kuwabara H, Ohashi Y, Shinoda K, Takano Y, Iwashiro N, Satomura Y, Nagai T, Natsubori T, Tada M, Yamasue H, Kasai K*. A snapshot of plasma metabolites in first-episode schizophrenia: A capillary electrophoresis time-of-flight mass spectrometry study. Translational Psychiatry 2014,4:e379.

  14. Murata Y, Nishioka M, Bundo M, Sunaga F, Kasai K, Iwamoto K*. Comprehensive DNA methylation analysis of human neuroblastoma cells treated with blonanserin. Neuroscience Letters 2014,563:123-128.

  15. Kubota-Sakashita M, Iwamoto K, Bundo M, Kato T*. A role of ADAR2 and RNA editing of glutamate receptors in mood disorders and schizophrenia. Molecular Brain 2014,7:5.

  16. Bundo M, Toyoshima M, Okada Y, Akamatsu W, Ueda J, Nemoto-Miyauchi T, Sunaga F, Toritsuka M, Ikawa D, Kakita A, Kato M, Kasai K, Kishimoto T, Nawa H, Okano H, Yoshikawa T, Kato T*, Iwamoto K*. Increased L1 retrotransposition in the neuronal genome in schizophrenia. Neuron 2014,81:306-313.

  17. Mehta D, Iwamoto K, Ueda J, Bundo M, Adati N, Kojima T, Kato T*. Comprehensive survey of CNVs influencing gene expression in the human brain and its implications for pathophysiology. Neuroscience Research in press

  18. Iwata A*, Nagata K, Hatsuta H, Takuma H, Bundo M, Iwamoto K, Tamaoka K, Murayama S, Saido T, Tsuji S. Altered CpG methylation in sporadic Alzheimer's disease is associated with APP and MAPT dysregulation. Human Molecular Genetics in press

  19. Ikegame T†, Bundo M†, Sunaga F, Asai T, Nishimura F, Yoshikawa A, Kawamura Y, Hibino H, Tochigi M, Kakiuchi C, Sasaki T, Kato T, Kasai K, Iwamoto K*. DNA methylation analysis of BDNF gene promoters in peripheral blood cells of schizophrenia patients. Neuroscience Research  2013,77:208-214.

  20. Asai T†, Bundo M†, Sugawara H, Sunaga F, Ueda J, Tanaka G, Ishigooka J, Kasai K, Kato T, Iwamoto K*. Effect of mood stabilizers on DNA methylation in human neuroblastoma cells. International Journal of Neuropsychopharmacology 2013,16:2285-2294.

  21. Nishioka M, Shimada T, Bundo M, Ukai W, Hashimoto E, Saito T, Kano Y, Sasaki T, Kasai K, Kato T*, Iwamoto K*. Neuronal cell-type specific DNA methylation patterns of the Cacna1c gene. International Journal of Developmental Neuroscience 2013,31:89-95.

  22. Nishioka M, Bundo M, Koike S, Takizawa R, Kakiuchi C, Araki T, Kasai K, Iwamoto K*. Comprehensive DNA methylation analysis of peripheral blood cells derived from patients with first-episode schizophrenia. Journal of Human Genetics 2013,58:91-97.

  23. Bundo M, Sunaga F, Ueda J, Kasai K, Kato T, Iwamoto K*. A systematic evaluation of whole genome amplfication of bisulfite-modified DNA. Clinical Epigenetics 2012,4:22.

  24. Sugawara H, Iwamoto K, Bundo M, Ueda J, Miyauchi T, Komori A, Kazuno AA, Adati N, Kusumi I, Okazaki Y, Ishigooka J, Kojima T, Kato T*. Hypermethylation of serotonin transporter gene in bipolar disorder detected by epigenome analysis of discordant monozygotic twins. Translational Psychiatry 2011,1:e24.

  25. Iwamoto K†*, Bundo M†, Ueda J, Oldham MC, Ukai W, Hashimoto E, Saito T, Geschwind DH, Kato T*. Neurons show distinctive DNA methylation profile and higher interindividual variations compared with non-neurons. Genome Research 2011,21:688-696.

  26. Iwamoto K*, Ueda J, Bundo M, Kojima T, Kato T*. Survey of the effect of genetic variations on gene expression in human prefrontal cortex and its application to genetics of psychiatric disorders. Neuroscience Research 2011,70:238-242.

  27. Sugawara H, Iwamoto K, Bundo M, Ueda J, Ishigooka J, Kato T*. Comprehensive DNA methylation analysis of human peripheral blood leukocytes and lymphoblastoid cell lines. Epigenetics 2011,6:508-515.

  28. Bundo M, Iwamoto K, Yamada K, Yoshikawa T, Kato T*. Mutation screening and assessment of the effect of genetic variations on expression and RNA editing of serotonin receptor 2C in the human brain. Psychiatry and Clinical Neurosciences 2010,64:57-61.

  29. Sugawara H, Iwamoto K, Bundo M, Ishiwata M, Ueda J, Kakiuchi C, Ishigooka J, Kato T*. Effect of mood stabilizers on gene expression in lymphoblastoid cells. Journal of Neural Transmission 2010,117:155-164.

  30. Washizuka S, Iwamoto K, Kakiuchi C, Bundo M, Kato T*. Expression of mitochondrial complex I subunit gene NDUFV2 in the lymphoblastoid cells derived from patients with bipolar disorder and schizophrenia. Neuroscience Research 2009,63:199-204.

  31. Sugawara H, Iwamoto K, Bundo M, Kazuno AA, Nakano Y, Ishigooka J, Kato T*. A 3-bp deletion of mitochondrial DNA tRNALys observed in lymphoblastoid cells. Journal of Human Genetics 2009,54:612-613.

  32. Tochigi M, Iwamoto K, Bundo M, Sasaki T, Kato N, Kato T*. Gene expression profiling of major depression and suicide in the prefrontal cortex of postmortem brains. Neuroscience Research 2008,60:184-191.

  33. Tochigi M, Iwamoto K, Bundo M, Komori A, Sasaki T, Kato N, Kato T*. Methylation status of the reelin promoter region in the brain of schizophrenic patients. Biological Psychiatry 2008,63:530-533.

  34. Kuratomi G, Iwamoto K, Bundo M, Kusumi I, Kato N, Iwata N, Ozaki N, Kato T*. Aberrant DNA methylation associated with bipolar disorder identified from discordant monozygotic twins. Molecular Psychiatry 2008,13:429-441.

  35. Iwamoto K*, Ueda J, Bundo M, Nakano Y, Kato T. Effect of a functional single nucleotide polymorphism in the 2',3'-cyclic nucleotide 3'-phosphodiesterase gene on the expression of oligodendrocyte-related genes in schizophrenia. Psychiatry and Clinical Neurosciences 2008,62:103-108.

  36. Iwamoto K, Ueda J, Nakano Y, Bundo M, Ukai W, Hashimoto E, Saito T, Kato T*. Evaluation of whole genome amplification methods using postmortem brain samples. Journal of Neuroscience Methods 2007,165:104-110.

  37. Iwamoto K*, Bundo M, Ueda J, Nakano Y, Ukai W, Hashimoto E, Saito T, Kato T. Detection of chromosomal structural alterations in single cells by SNP arrays: a systematic survey of amplification bias and optimized workflow. PLoS One 2007,2:e1306.

  38. Kohda K*, Jinde S, Iwamoto K, Bundo M, Kato N, Kato T. Maternal separation stress drastically decreases expression of transthyretin in the brains of adult rat offspring. International Journal of Neuropsychopharmacology 2006,9:201-208.

  39. Iwamoto K, Bundo M, Yamada K, Takao H, Iwayama Y, Yoshikawa T, Kato T*. A family-based and case-control association study of SOX10 in schizophrenia. American Journal of Medical Genetics PartB: Neuropsychiatric Genetics 2006,141B:477-481.

  40. Iwamoto K*, Bundo M, Ueda J, Kato T. Expression of ribosomal subunit genes increased coordinately with postmortem interval in human brain. Molecular Psychiatry 2006,11:1067-1069.

  41. Munakata K, Iwamoto K, Bundo M, Kato T*. Mitochondrial DNA 3243A>G mutation and increased expression of LARS2 gene in the brains of patients with bipolar disorder and schizophrenia. Biological Psychiatry 2005,57:525-532.

  42. Munakata K*, Bundo M, Kato T, Ono H, Sakura N, Oosaki M, Waki C, Tanaka M. Co-existing point mutations of mitochondrial DNA in a patient with a heart abnormality and Pearson syndrome-like symptoms. American Journal of Medical Genetics PartA 2005,139A:162-164.

  43. Iwamoto K*, Nakatani N, Bundo M, Yoshikawa T, Kato T. Altered RNA editing of serotonin 2C receptor in a rat model of depression. Neuroscience Research 2005,53:69-76.

  44. Iwamoto K*, Bundo M, Yamada K, Takao H, Iwayama-Shigeno Y, Yoshikawa T, Kato T. DNA methylation status of SOX10 correlates with its downregulation and oligodendrocyte dysfunction in schizophrenia. Journal of Neuroscience 2005,25:5376-5381.

  45. Iwamoto K†*, Bundo M†, Kato T. Estimating RNA editing efficiency of five editing sites in the serotonin 2C receptor by pyrosequencing. RNA 2005,11:1596-1603.

  46. Iwamoto K, Bundo M, Kato T*. Altered expression of mitochondria-related genes in postmortem brains of patients with bipolar disorder or schizophrenia, as revealed by large-scale DNA microarray analysis. Human Molecular Genetics 2005,14:241-253.

  47. Iwamoto K, Kakiuchi C, Bundo M, Ikeda K, Kato T*. Molecular characterization of bipolar disorder by comparing gene expression profiles of postmortem brains of major mental disorders. Molecular Psychiatry 2004,9:406-416.

  48. Iwamoto K, Bundo M, Yamamoto M, Ozawa H, Saito T, Kato T*. Decreased expression of NEFH and PCP4/PEP19 in the prefrontal cortex of alcoholics. Neuroscience Research 2004,49:379-385.

  49. Iwamoto K, Bundo M, Washizuka S, Kakiuchi C, Kato T*. Expression of HSPF1 and LIM in the lymphoblastoid cells derived from patients with bipolar disorder and schizophrenia. Journal of Human Genetics 2004,49:227-231.

  50. Kakiuchi C, Iwamoto K, Ishiwata M, Bundo M, Kasahara T, Kusumi I, Tsujita T, Okazaki Y, Nanko S, Kunugi H, Sasaki T, Kato T*. Impaired feedback regulation of XBP1 as a genetic risk factor for bipolar disorder. Nature Genetics 2003,35:171-175.

  51. Yanagisawa H, Bundo M, Miyashita T, Okamura-Oho Y, Tadokoro K, Tokunaga K, Yamada M*. Protein binding of a DRPLA family through arginine-glutamic acid dipeptide repeats is enhanced by extended polyglutamine. Human Molecular Genetics 2000,9:1433-1442.

  52. Nagafuchi S, Yanagisawa H, Sato K, Shirayama T, Ohsaki E, Bundo M, Takeda T, Tadokoro K, Kondo I, Murayama N, et al. Dentatorubral and pallidoluysian atrophy expansion of an unstable CAG trinucleotide on chromosome 12p. Nature Genetics 1994,6:14-18.

 

英文総説など

  1. Bundo M*, Kato T, Iwamoto K. Estimation of LINE-1 Copy Number in the Brain Tissue and Isolated Neuronal Nuclei. In: Frade J., Gage F. (eds) Genomic Mosaicism in Neurons and Other Cell Types. Neuromethods, 2017 vol 131. Humana Press, New York, NY

  2. Bundo M*, Kato T, Iwamoto K. Cell Type-Specific DNA Methylation Analysis in Neurons and Glia. In: Karpova N. (eds) Epigenetic Methods in Neuroscience Research. Neuromethods, 2016 vol 105. Humana Press, New York, NY

  3. Ikegame T, Bundo M, Murata Y, Kasai K, Kato T, Iwamoto K*. DNA methylation of the BDNF gene and its relevance to psychiatric disorders. Journal of Human Genetics 2013,58:434-438.

  4. Sugawara H, Bundo M, Ishigooka J, Iwamoto K, Kato T*. Epigenetic regulation of serotonin transporter in psychiatric disorders. Journal of Genetics and Genomics 2013,40:325-329

  5. Nishioka M, Bundo M, Kasai K, Iwamoto K*. DNA methylation in schizophrenia: progress and challenges of epigenetic studies. Genome Medicine 2012,4:96.

  6. Iwamoto K*, Bundo M, Kasai K, Kato T. Measuring RNA editing of serotonin 2C receptor. Biochemistry (Moscow) 2011,76:912-914.

  7. Iwamoto K*, Bundo M., Kato T. RNA Editing of 5-HT2C Receptor and Neuropsychiatric Diseases. In: Di Giovanni G., Esposito E., Di Matteo V. (eds) 5-HT2C Receptors in the Pathophysiology of CNS Disease. The Receptors, 2011, vol 22. Humana Press, Totowa, NJ

  8. Iwamoto K*, Bundo M, Kato T. Serotonin receptor 2C and mental disorders: genetic, expression and RNA editing studies. RNA Biology 2009,6:248-253.

 

日本語総説など

  1. 澤村理英、文東美紀、岩本和也、統合失調症とエピジェネティクス、精神科「統合失調症の研究最前線」(科学評論社、2018 32 (3):189-193)

  2. Watanabe R, Nishioka M, Bundo M, Sawai Y, Ueda J, Murata Y, Ishii T, Ukai W, Hashimoto E, Kasai K, Simizu S, Kato T, Iwamoto K. Epigenetic status of LINE-1 promoters in neurons and non-neurons. 日本神経精神薬理学雑誌(2017 37:83-84)

  3. 菅原裕子、文東美紀、池亀天平、近藤健治、池田匡志、岩田仲生、石郷岡純、笠井清登、加藤忠史、岩本和也 統合失調症と双極性障害における共通ならびに特有のエピジェネティック要因についての検討 日本神経精神薬理学雑誌 (2017 37:81)

  4. 菅原裕子、日高洋介、文東美紀、岩本和也 精神ストレスとエピゲノム応答 最新医学 (2017 72,5, p733-739)

  5. 西岡将基、文東美紀、笠井清登、岩本和也 次世代シークエンサーを用いた脳ゲノム解析 分子精神医学(先端医学社、2016 16:180-185)

  6. 村田唯、文東美紀、笠井清登、岩本和也 統合失調症におけるエピゲノム異常~患者由来脳組織および末梢組織を用いた最新研究、実験医学増刊「エピゲノム研究~修飾の全体像の理解から先制・個別化医療へ」(羊土社、2016、p140-144)

  7. 緒方優、池亀天平、文東美紀、笠井清登、岩本和也 セロトニントランスポーターのDNAメチル化と精神疾患、日本生物学的精神医学会誌 2015, 26:3-6

  8. 池亀天平、文東美紀、笠井清登、岩本和也 精神疾患におけるエピゲノム研究、分子精神医学 2015,15:87-94

  9. 菅原裕子、文東美紀、石郷岡純、加藤忠史、岩本和也 精神疾患とエピジェネティクス、生体の科学 2014,65:595-600

  10. 村田唯、文東美紀、笠井清登 岩本和也 精神疾患とエピジェネティクス―治療薬の作用機序の観点から、臨床精神薬理 2014,17:1663-1666

  11. 文東美紀、加藤忠史、岩本和也 統合失調症の患者死後脳ではLINE-1配列が増加している、科学 2014,84:808-810

  12. 池亀天平、文東美紀、笠井清登、岩本和也 第4編第8章 精神疾患におけるエピジェネティクス解析、エピジェネティクスの産業応用 畑田出穂、久保田健夫監修 シーエムシー出版 2014:p232-238

  13. 文東美紀、加藤忠史、岩本和也 統合失調症の神経細胞ゲノムではLINE-1のコピー数が増加している、実験医学 2014,32:1257-1260

  14. 文東美紀、加藤忠史、岩本和也 LINE-1、分子精神医学 2014,14:138-139

  15. 池亀天平、文東美紀、笠井清登、岩本和也 統合失調症におけるエピジェネティクス解析、生体の科学 2014,65:55-59

  16. 岩本和也、文東美紀、加藤忠史 第15章 「精神疾患のエピジェネティクス」 エピジェネティクス―その分子機構から高次生命機能まで 田嶋正二/編 化学同人 2013

  17. 村田唯、文東美紀、岩本和也 第3部第7章 「精神疾患」 イラストで徹底理解するエピジェネティクスキーワード事典―分子機構から疾患・解析技術まで 牛島俊和,眞貝洋一/編 羊土社 2013:p215-219

  18. 村田唯、文東美紀、岩本和也 エピジェネティクス、脳科学辞典

  19. 西岡将基、文東美紀、笠井清登、岩本和也 統合失調症におけるエピジェネティクス研究の現状と課題、日本臨床 2013,71:605-609

  20. 岩本和也、文東美紀、笠井清登、加藤忠史、気分障害におけるエピゲノム解析、気分障害の薬理・生化学~うつ病の脳内メカニズム研究:進歩と挑戦  躁うつ病の薬理・生化学的研究懇話会編、医薬ジャーナル社 2012,6:287-292

  21. 文東美紀、笠井清登、加藤忠史、岩本和也 脳ゲノム多様性と精神疾患、日本生物学的精神医学会誌 2012,23:29-33

  22. 浅井竜朗、文東美紀、笠井清登、岩本和也 精神疾患のエピジェネティクス、チャイルドヘルス 2012,15:182-184

  23. 西岡将基、文東美紀、笠井清登、岩本和也 統合失調症のエピジェネティクス、精神科治療学 2011,26:1371-1377

  24. 岩本和也、文東美紀 DNAメチル化研究の最新の動向、分子精神医学 2011,11:90-93

  25. 加藤忠史、文東美紀、岩本和也 神経細胞のDNAメチル化、分子精神医学 2011,11:112-117

  26. 文東美紀、岩本和也、加藤忠史 セロトニン2C受容体、生体の科学 2010,61:394-396

  27. 文東美紀、岩本和也 気分障害患者の死後脳におけるオミックス研究、Medical Bio 2010,48:46-51

  28. 文東美紀、岩本和也、加藤忠史 精神疾患におけるPyrosequencingの利用、エピジェネティクス関連Protocol 羊土社 2008