Articles (since 2016) 

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1. Du J†, Nakachi Y†, Murata Y, Kiyota E, Kato T, Bundo M*, Iwamoto K*.
   Exploration of cell-type-specific somatic mutations in schizophrenia and the impact of maternal immune activation on the somatic mutation profile in the brain.
   Psychiatry and Clinical Neurosciences, in press
    

2. Baba Y, Yasuda N, Bundo M, Nakachi Y, Ueda J, Ishimoto T, Iwatsuki M, Miyamoto Y, Yoshida N, Oshiumi H, Iwamoto K, Baba H*.
   LINE-1 hypomethylation, increased retrotransposition and tumor-specific insertion in upper gastrointestinal cancer.
   Cancer Science, 00:1-10,2023
   doi:10.1111/cas.16007
    

3. Sugawara H†, Date A†, Fuke S, Nakachi Y, Kato T, Narita M, Bundo M*, Iwamoto K*.
   Quantification of cytosine modifications in the aged mouse brain
   Neuropsychopharmacology Reports, 00:1–6, 2023
   doi: 10.1002/npr2.12396
    

4. Fujii S†, Murata Y†, Imamura Y, Nakachi Y, Bundo M, Kubota-Sakashita M, Kato T, Iwamoto K*.
   Sex-dependent behavioral alterations in a poly(I:C)-induced maternal immune activation mouse model without segment filamentous bacteria.
   Neuroscience Letters, 814:137467, 2023
   doi.org/10.1016/j.neulet.2023.137467
    

5. Kajitani N, Okada-Tsuchioka M, Inoue A, Miyano K, Masuda T, Boku S, Iwamoto K, Ohtsuki S, Uezono Y, Aoki J, Takebayashi M.
   G protein-biased LPAR1 agonism of prototypic antidepressants: Implication in the identification of novel therapeutic target for depression
   Neuropsychopharmacology, 2023
   doi: 10.1038/s41386-023-01727-9
    

6. Hu X, Yasuda T, Yasuda-Yosihara N, Yonemura A, Umemoto T, Nakachi Y, Yamashita K, Semba T, Arima K, Uchihara T, Nishimurav K, Bu L, Fu L, Wei F, Zhang J, Tong Y, Wang H, Iwamoto K, Fukuda T, Nakagawa H, Taniguchi K, Miyamoto Y, Baba H, Ishimoto T.
   Downregulation of 15-PGDH enhances MASH-HCC development via fatty acid-induced T-cell exhaustion.
   JHEP Reports, 5,100892, 2023
   https://doi.org/10.1016/j.jhepr.2023.100892
    

7. Watanabe R, Nakachi Y, Matsubara H, Ueda J, Ishii T, Ukai W, Hashimoto E, Kasai K, Simizu S, Kato T, Bundo M*, Iwamoto K*.
   Identification of epigenetically active L1 promoters in the human brain and their relationship with psychiatric disorders.
   Neuroscience Research, 195: 37-51, 2023
   doi: 10.1016/j.neures.2023.05.001.
    

8. Yu Z*, Ueno K, Funayama R, Sakai M, Nariai N, Kojima K, Kikuchi Y, Li Z, Ono C, Kanatani J, Ono J, Iwamoto K, Hashimoto K, Kinoshita K, Nakayama K, Nagasaki M, Tomita H.
   Sex-Specific Differences in the Transcriptome of the Human Dorsolateral Prefrontal Cortex in Schizophrenia.
   Molecular Neurobiology 60(2):1083-1098, 2023
   doi: 10.1007/s12035-022-03109-6
    

9. Inoue H, Hirasaki M, Kogashiwa Y, Nakachi Y, Kuba K, Ebihara Y, Nakahira M, Yasuda M, Okuda A, Sugasawa M.
   Identification of novel oncogenes in oral cancer among elderly nonsmokers. 
   Clinical and Experimental Dental Research 9(4): 711-720, 2023
   doi: 10.1002/cre2.739
    

10. Du J†, Nakachi Y†, Fujii A, Fujii S, Bundo M*, Iwamoto K*.
    Antipsychotics function as epigenetic age regulators in human neuroblastoma cells
    Schizophrenia (Heidelb), 8(1):69, 2022
    doi: 10.1038/s41537-022-00277-1
     

11. Sugawara H†, Bundo M†, Kasahara T, Nakachi Y, Ueda J, Kubota-Sakashita M, Iwamoto K*, Kato T*.
    Cell-type-specific DNA methylation analysis of the frontal cortices of mutant Polg1 transgenic mice with neuronal accumulation of deleted mitochondrial DNA.
    Molecular Brain, 15:9, 2022
    doi: 10.1186/s13041-021-00894-4
      

12. Du J†, Nakachi Y†, Kiyono T, Fujii S, Kasai K, Bundo M*, Iwamoto K*.
    Comprehensive DNA methylation analysis of human neuroblastoma cells treated with haloperidol and risperidone
    Frontiers in Molecular Neuroscience, 14:792874, 2021
    doi:10.3389/fnmol.2021.792874
     

13. Ueda J†, Bundo M†, Nakachi Y, Kasai K, Kato T*, Iwamoto K*.
    Cell type-specific DNA methylation analysis of the prefrontal cortex of patients with schizophrenia.
    Psychiatry and Clinical Neurosciences, 75:297-299, 2021
    doi: 10.1111/PCN.13282
     

14. Kobayashi Y, Inaba H, Iwakura Y, Namba H, Sotoyama H, Murata Y, Iwamoto K, Nawa H*.
    Inter-breeder differences in prepulse inhibition deficits of C57BL/6J mice in a maternal infection model for schizophrenia.
    Neuropsychopharmacology Reports, 41:416-421, 2021
    doi: 10.1002/npr2.12178
     

15. Bundo M†, Ueda J†, Nakachi Y, Kasai K, Kato T*, Iwamoto K*.
    Decreased DNA methylation at promoters and gene-specific neuronal hypermethylation in the prefrontal cortex of patients with bipolar disorder. 
    Molecular Psychiatry, 26:3407-3418, 2021
    doi: 10.1038/s41380-021-01079-0
     

16. Maeshiro M, Shinriki S*, Liu R, Nakachi Y, Komohara Y, Fujiwara Y, Ohtsubo K, Yoshida R, Iwamoto K, Nakayama H, Matsui H*.
    Colonization of distant organs by tumor cells generating circulating homotypic clusters adaptive to fluid shear stress.
    Scientific Reports, 11:6150, 2021
    doi: 10.1038/s41598-021-85743-z
     

17. Ikegame T†, Hidaka Y†, Nakachi Y, Murata Y, Watanabe R, Sugawara H, Asai T, Kiyota E, Saito T, Ikeda M, Sasaki T, Hashimoto M, Ishikawa T, Takebayashi M, Iwata N, Kakiuchi C, Kato T, Kasai K, Bundo M*, Iwamoto K*.
    Identification and functional characterization of the extremely long allele of the serotonin transporter-linked polymorphic region. 
    Translational Psychiatry, 11:119, 2021
    doi: 10.1038/s41398-021-01242-9
     

18. Wada Y, Maekawa M*, Ohnishi T, Balan S, Matsuoka S, Iwamoto K, Iwayama Y, Ohba H, Watanabe A, Hisano Y, Nozaki Y, Toyota T, Shimogori T, Itokawa M, Kobayashi T, Yoshikawa T*.
    Peroxisome proliferator-activated receptor α as a novel therapeutic target for schizophrenia.
    EBioMedicine, 62:103130, 2020
    doi:10.1016/j.ebiom.2020.103130
     

19. Nakachi Y, Ishii K, Bundo M, Masuda T*, Iwamoto K*.
    Use of the Illumina EPIC methylation array for epigenomic research in the crab-eating macaque (Macaca fascicularis). 
    Neuropsychopharmacology Reports, 40:423-426, 2020
    doi:10.1002/npr2.12145
     

20. Kuroki R†, Murata Y†, Fuke S, Nakachi Y, Nakashima J, Kujoth GC, Prolla TA, Bundo M, Kato T, Iwamoto K.*
    Establishment of qPCR assays for active LINE-1 subfamilies in mice and applications to the analysis of aging-associated retrotransposition,
    Frontiers in Genetics, 11:519206, 2020
    doi: 10.3389/fgene.2020.519206
     

21. Ikegame T†, Bundo M†, Okada N, Murata Y, Koike S, Sugawara H, Saito T, Ikeda M, Owada K, Fukunaga M, Yamashita F, Koshiyama D, Natsubori T, Iwashiro N, Asai T, Yoshikawa A, Nishimura F, Kawamura Y, Ishigooka J, Kakiuchi C, Sasaki T, Abe O, Hashimoto R, Iwata N, Yamasue H, Kato T, Kasai K, Iwamoto K*.​
    Promoter activity-based case-control association study on SLC6A4 highlighting hypermethylation and altered amygdala volume in male patients with schizophrenia.
    Schizophrenia Bulletin, 46:1577-1586, 2020
    doi: 10.1093/schbul/sbaa075
     

22. Murata Y, Ikegame T, Koike S, Saito T, Ikeda M, Sasaki T, Iwata N, Kasai K, Bundo M*, Iwamoto K*.
    Global DNA hypomethylation and its correlation to the betaine level in peripheral blood of patients with schizophrenia.
    Progress in Neuropsychopharmacology & Biological Psychiatry, 99:109855, 2020.
    doi: 10.1016/j.pnpbp.2019.109855
     

23. Zhao Z, Jinde S*, Koike S, Tada M, Satomura Y, Yoshikawa A, Nishimura Y, Takizawa R, Kinoshita A, Sakakibara E, Sakurada H, Yamagishi M, Nishimura F, Inai A, Nishioka M, Eriguchi Y, Araki T, Takaya A, Kan C, Umeda M, Shimazu A, Hashimoto H, Bundo M, Iwamoto K, Kakiuchi C, Kasai K.
    Altered expression of microRNA-223 in the plasma of patients with first-episode schizophrenia and its possible relation to neuronal migration-related genes.
    Translational Psychiatry, 9:289, 2019.
    doi: 10.1038/s41398-019-0609-0
     

24. Ide M†, Ohnishi T†, Toyoshima M, Balan S, Maekawa M, Shimamoto-Mitsuyama C, Iwayama Y, Ohba H, Watanabe A, Ishii T, Shibuya N, Kimura Y, Hisano Y, Murata Y, Hara T, Morikawa M, Hashimoto K, Nozaki Y, Toyota T, Wada Y, Tanaka Y, Kato T, Nishi A, Fujisawa S, Okano H, Itokawa M, Hirokawa N, Kunii Y, Kakita A, Yabe H, Iwamoto K, Meno K, Katagiri T, Dean B, Uchida K, Kimura H, Yoshikawa T*.
    Excess hydrogen sulfide and polysulfides production underlies a schizophrenia pathophysiology.
    EMBO Molecular Medicine, e10695, 2019.
    doi: 10.15252/emmm.201910695
     

25. Murata Y†, Fujii A†, Kanata S, Fujikawa S, Ikegame T, Nakachi Y, Zhao Z, Jinde S, Kasai K, Bundo M*, Iwamoto K*.
    Evaluation of the usefulness of saliva for DNA methylation analysis in cohort studies.
    Neuropsychopharmacology Reports, 39:301-305, 2019.
    doi: 10.1002/npr2.12075
     

26. Okada N, Ando S, Sanada M, Hirata‐Mogi S, Iijima Y, Sugiyama H, Shirakawa T, Yamagishi M, Kanehara A, Morita M, Yagi T, Hayashi N, Koshiyama D, Morita K, Sawada K, Ikegame T, Sugimoto N, Toriyama R, Masaoka M, Fujikawa S, Kanata S, Tada M, Kirihara K, Yahata N, Araki T, Jinde S, Kano Y, Koike S, Endo K, Yamasaki S, Nishida A, Hiraiwa‐Hasegawa M, Bundo M, Iwamoto K, Tanaka SC, Kasai K*.
    The population‐neuroscience study of the Tokyo TEEN Cohort (pn‐TTC): a cohort longitudinal study to explore the neurobiological substrates of adolescent psychological and behavioral development.
    Psychiatry and Clinical Neurosciences, 73:231-242, 2019.
    doi: 10.1111/pcn.12814
     

27. Murata Y, Bundo M*, Sunaga F, Kasai K, Iwamoto K*.
    DNA methylation profiling in a neuroblastoma cell line exposed to the antipsychotic perospirone.
    Pharmacopsychiatry, 52:63-69, 2019.
    doi: 10.1055/s-0044-101467
     

28. Nishioka M, Bundo M, Ueda J, Yoshikawa A, Nishimura F, Sasaki T, Kakiuchi C, Kasai K, Kato T*, Iwamoto K*.
    Identification of somatic mutations in monozygotic twins discordant for psychiatric disorders.
    npj Schizophrenia, 4:7, 2018.
    doi: 10.1038/s41537-018-0049-5
     

29. Miura I*, Kunii Y, Hino M, Hoshino H, Matsumoto K, Kanno-Nozaki K, Horikoshi S, Kaneko H, Bundo M, Iwamoto K, Yabe H.
    DNA methylation of ANKK1 and response to aripiprazole in patients with acute schizophrenia: A preliminary study.
    Journal of Psychiatric Research, 100:84-87, 2018.
    doi: 10.1016/j.jpsychires.2018.02.018
     

30. Sugawara H, Murata Y, Ikegame T, Sawamura R, Shimanaga S, Takeoka Y, Saito T, Ikeda M, Yoshikawa A, Nishimura F, Kawamura Y, Kakiuchi C, Sasaki T, Iwata N, Hashimoto M, Kasai K, Kato T, Bundo M*, Iwamoto K*.
    DNA methylation analyses of the candidate genes identified by a methylome-wide association study revealed common epigenetic alterations in schizophrenia and bipolar disorder.
    Psychiatry and Clinical Neurosciences, 72:245-254, 2018.
    doi: 10.1111/pcn.12645
     

31. Shimada-Sugimoto M, Otowa T*, Miyagawa T, Umekage T, Kawamura Y, Bundo M, Iwamoto K, Ikegame T, Tochigi M, Kasai K, Kaiya H, Tanii H, Okazaki Y, Tokunaga K, Sasaki T.
    An epigenome-wide methylation study of healthy individuals with or without depressive symptoms.
    Journal of Human Genetics​, 63:319-326, 2018.
    doi: 10.1038/s10038-017-0382-y
     

32. Nishioka M, Bundo M, Ueda J, Katsuoka F, Sato Y, Kuroki Y, Ishii T, Ukai W, Murayama S, Hashimoto E, Nagasaki M, Yasuda J, Kasai K, Kato T*, Iwamoto K​*.
    Identification of somatic mutations in postmortem human brains by whole genome sequencing and their implications for psychiatric disorders.
    Psychiatry and Clinical Neurosciences, 72:280-294, 2018.
    doi: 10.1111/pcn.12632
     

33. Yoshikawa A, Nishimura F, Inai, A, Eriguchi, Y, Nishioka, M, Takaya A, Tochigi M, Kawamura Y, Umekage T, Kato K, Sasaki T, Ohashi Y, Iwamoto K, Kasai K, Kakiuchi C*.
    Mutations of the glycine cleavage system genes possibly affect the negative symptoms of schizophrenia through metabolomic profile changes.
    Psychiatry and Clinical Neurosciences, 72:168-179, 2018.
    doi: 10.1111/pcn.12628
     

34. Murata Y, Bundo M, Ueda J, Kubota-Sakashita M, Kasai K, Kato T, Iwamoto K*.
    DNA methylation and hydroxymethylation analyses of the active LINE-1 subfamilies in mice.
    Scientific Reports, 7:13624, 2017.
    doi: 10.1038/s41598-017-14165-7
     

35. Maekawa M, Watanabe A, Iwayama Y, Kimura T, Hamazaki K, Balan S, Ohba H, Hisano Y, Nozaki Y, Ohnishi T, Toyoshima M, Shimamoto C, Iwamoto K, Bundo M, Osumi N, Takahashi E, Takashima A, Yoshikawa T*.
    Polyunsaturated fatty acid deficiency during neurodevelopment in mice models the prodromal state of schizophrenia through epigenetic changes in nuclear receptor genes.
    Translational Psychiatry, 7:e1229, 2017.
    doi: 10.1038/tp.2017.182
     

36. Ueda J†, Murata Y†, Bundo M, Oh-Nishi A, Kassai H, Ikegame T, Zhao Z, Jinde S, Aiba A, Suhara T, Kasai K, Kato T, Iwamoto K*.
    Use of human methylation arrays for epigenome research in the common marmoset (Callithrix jacchus).
    Neuroscience Research, 120:60-65, 2017.
    doi: 10.1016/j.neures.2017.02.005
     

37. Shimada-Sugimoto M, Otowa T*, Miyagawa T, Umekage T, Kawamura Y, Bundo M, Iwamoto K, Tochigi M, Kasai K, Kaiya H, Tanii H, Okazaki Y, Tokunaga K, Sasaki T.
    Epigenome-wide association study of DNA methylation in panic disorder.
    Clinical Epigenetics, 9:6, 2017.
    doi: 10.1186/s13148-016-0307-1
     

38. Kasahara T, Ishiwata M, Kakiuchi C, Fuke S, Iwata N, Ozaki N, Kunugi H, Minabe Y, Nakamura K, Iwata Y, Fujii K, Kanba S, Ujike H, Kusumi I, Kataoka M, Matoba N, Takata A, Iwamoto K, Yoshikawa T, Kato T*.
    Enrichment of deleterious variants of mitochondrial DNA polymerase gene (POLG1) in bipolar disorder.
    Psychiatry and Clinical Neurosciences, 71:518-529, 2017.
    doi: 10.1111/pcn.12496

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Reviews and book chapters (since 2016) 

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1. Bundo M*, Iwamoto K.
   A method for detection of somatic LINE-1 insertions at the single-cell level from postmortem human brain
   In: Hatada I and Horii T (eds) Epigenomics
   Methods in Molecular Biology, 2577:147-159, 2023. Humana Press, New York, NY.
   doi: 10.1007/978-1-0716-2724-2_10
    

2. Nishioka M, Bundo M, Iwamoto K*, Kato T*. 
   Somatic mutations in the human brain: implications for psychiatric research.
   Molecular Psychiatry, 24:839-856, 2019.
   doi: 10.1038/s41380-018-0129-y
    

3. Iwamoto K*. 
   Understanding the epigenetic architecture of psychiatric disorders: modifications and beyond.
   Psychiatry and Clinical Neurosciences, 72:194, 2018.
   doi: 10.1111/pcn.12646
    

4. Bundo M*, Kato T, Iwamoto K.
   Estimation of LINE-1 Copy Number in the Brain Tissue and Isolated Neuronal Nuclei.
   In: Frade J., Gage F. (eds) Genomic Mosaicism in Neurons and Other Cell Types. 
   Neuromethods, 2017 vol 131. Humana Press, New York, NY
   doi: 10.1007/978-1-4939-7280-7_11

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