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About us

岩本和也　博士 (理学)​

Kazuya Iwamoto, Ph.D.

​

  • 1996年　東京農工大学農学部応用生物科学科卒業

  • 1998年　東京大学大学院理学系研究科生物科学専攻修士課程修了

  • 2001年　東京大学大学院理学系研究科生物科学専攻博士課程修了

  • 2001年～2004年　理化学研究所脳科学総合研究センター研究員

  • 2004年～2007年　理化学研究所　基礎科学特別研究員

  • 2007年～2010年　理化学研究所脳科学総合研究センター研究員

  • 2010年～2016年　東京大学大学院医学系研究科分子精神医学講座特任准教授

  • 2011年～2015年　科学技術振興機構さきがけ研究員（兼任）

  • 2010年～2013年　理化学研究所脳科学総合研究センター客員研究員

  • 2013年～2016年　東京大学大学院理学系研究科生物科学専攻併任教員

  • 2016年～2020年　東京大学大学院理学系研究科生物科学専攻協力教員

  • 2013年～現在　理化学研究所脳科学総合研究センター客員主幹研究員

  • 2016年～現在　熊本大学大学院生命科学研究部分子脳科学分野教授

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　原著論文　

  1. Kobayashi Y, Inaba H, Iwakura Y, Namba H, Sotoyama H, Murata Y, Iwamoto K, Nawa H*.
    Inter-breeder differences in prepulse inhibition deficits of C57BL/6J mice in a maternal infection model for schizophrenia.
    Neuropsychopharmacology Reports, in press

  2. Bundo M†, Ueda J†, Nakachi Y, Kasai K, Kato T*, Iwamoto K*.
    Decreased DNA methylation at promoters and gene-specific neuronal hypermethylation in the prefrontal cortex of patients with bipolar disorder.
    Molecular Psychiatry in press

  3. Maeshiro M, Shinriki S*, Liu R, Nakachi Y, Komohara Y, Fujiwara Y, Ohtsubo K, Yoshida R, Iwamoto K, Nakayama H, Matsui H*. Colonization of distant organs by tumor cells generating circulating homotypic clusters adaptive to fluid shear stress.
    Scientific Reports, 11:6150, 2021

  4. Ikegame T†, Hidaka Y†, Nakachi Y, Murata Y, Watanabe R, Sugawara H, Asai T, Kiyota E, Saito T, Ikeda M, Sasaki T, Hashimoto M, Ishikawa T, Takebayashi M, Iwata N, Kakiuchi C, Kato T, Kasai K, Bundo M*, Iwamoto K*.
    Identification and functional characterization of the extremely long allele of the serotonin transporter-linked polymorphic region. 
    Translational Psychiatry, 11:119, 2021

  5. Wada Y, Maekawa M*, Ohnishi T, Balan S, Matsuoka S, Iwamoto K, Iwayama Y, Ohba H, Watanabe A, Hisano Y, Nozaki Y, Toyota T, Shimogori T, Itokawa M, Kobayashi T, Yoshikawa T*.
    Peroxisome proliferator-activated receptor α as a novel therapeutic target for schizophrenia.
    EBioMedicine, 62:103130, 2020

  6. Nakachi Y, Ishii K, Bundo M, Masuda T*, Iwamoto K*.
    Use of the Illumina EPIC methylation array for epigenomic research in the crab-eating macaque (Macaca fascicularis).
    Neuropsychopharmacology Reports, 40:423-426, 2020

  7. Kuroki R†, Murata Y†, Fuke S, Nakachi Y, Nakashima J, Kujoth GC, Prolla TA, Bundo M, Kato T, Iwamoto K.*
    Establishment of qPCR assays for active LINE-1 subfamilies in mice and applications to the analysis of aging-associated retrotransposition. 
    Frontiers in Genetics, 11:519206, 2020

  8. Ikegame T†, Bundo M†, Okada N, Murata Y, Koike S, Sugawara H, Saito T, Ikeda M, Owada K, Fukunaga M, Yamashita F, Koshiyama D, Natsubori T, Iwashiro N, Asai T, Yoshikawa A, Nishimura F, Kawamura Y, Ishigooka J, Kakiuchi C, Sasaki T, Abe O, Hashimoto R, Iwata N, Yamasue H, Kato T, Kasai K, Iwamoto K*.​
    Promoter activity-based case-control association study on SLC6A4 highlighting hypermethylation and altered amygdala volume in male patients with schizophrenia. 
    Schizophrenia Bulletin, 46:1577-1586, 2020

  9. Murata Y, Ikegame T, Koike S, Saito T, Ikeda M, Sasaki T, Iwata N, Kasai K, Bundo M*, Iwamoto K*.
    Global DNA hypomethylation and its correlation to the betaine level in peripheral blood of patients with schizophrenia. 
    Progress in Neuropsychopharmacology & Biological Psychiatry, 99:109855, 2020.

  10. Zhao Z, Jinde S*, Koike S, Tada M, Satomura Y, Yoshikawa A, Nishimura Y, Takizawa R, Kinoshita A, Sakakibara E, Sakurada H, Yamagishi M, Nishimura F, Inai A, Nishioka M, Eriguchi Y, Araki T, Takaya A, Kan C, Umeda M, Shimazu A, Hashimoto H, Bundo M, Iwamoto K, Kakiuchi C, Kasai K.
    Altered expression of microRNA-223 in the plasma of patients with first-episode schizophrenia and its possible relation to neuronal migration-related genes.
    Translational Psychiatry, 9:289, 2019.

  11. Ide M†, Ohnishi T†, Toyoshima M, Balan S, Maekawa M, Shimamoto-Mitsuyama C, Iwayama Y, Ohba H, Watanabe A, Ishii T, Shibuya N, Kimura Y, Hisano Y, Murata Y, Hara T, Morikawa M, Hashimoto K, Nozaki Y, Toyota T, Wada Y, Tanaka Y, Kato T, Nishi A, Fujisawa S, Okano H, Itokawa M, Hirokawa N, Kunii Y, Kakita A, Yabe H, Iwamoto K, Meno K, Katagiri T, Dean B, Uchida K, Kimura H, Yoshikawa T*.
    Excess hydrogen sulfide and polysulfides production underlies a schizophrenia pathophysiology.
    EMBO Molecular Medicine, e10695, 2019.

  12. Murata Y†, Fujii A†, Kanata S, Fujikawa S, Ikegame T, Nakachi Y, Zhao Z, Jinde S, Kasai K, Bundo M*, Iwamoto K*.
    Evaluation of the usefulness of saliva for DNA methylation analysis in cohort studies.
    Neuropsychopharmacology Reports, in press

  13. Okada N, Ando S, Sanada M, Hirata‐Mogi S, Iijima Y,  Sugiyama H, Shirakawa T, Yamagishi M, Kanehara A, Morita M, Yagi T, Hayashi N, Koshiyama D, Morita K, Sawada K, Ikegame T, Sugimoto N, Toriyama R, Masaoka M, Fujikawa S, Kanata S, Tada M, Kirihara K, Yahata N, Araki T, Jinde S, Kano Y, Koike S, Endo K, Yamasaki S, Nishida A, Hiraiwa‐Hasegawa M, Bundo M, Iwamoto K, Tanaka SC, Kasai K*.
    The population‐neuroscience study of the Tokyo TEEN Cohort (pn‐TTC): a cohort longitudinal study to explore the neurobiological substrates of adolescent psychological and behavioral development.
    Psychiatry and Clinical Neurosciences, 73:231-242, 2019

  14. Murata Y, Bundo M*, Sunaga F, Kasai K, Iwamoto K*.
    DNA methylation profiling in a neuroblastoma cell line exposed to the antipsychotic perospirone.
    Pharmacopsychiatry, 52:63-69, 2019

  15. Nishioka M, Bundo M, Ueda J, Yoshikawa A, Nishimura F, Sasaki T, Kakiuchi C, Kato T, Iwamoto K.
    Identification of somatic mutations in monozygotic twins discordant for psychiatric disorders.
    npj Schizophrenia, 4:7, 2018

  16. Miura I*, Kunii Y, Hino M, Hoshino H, Matsumoto K, Kanno-Nozaki K, Horikoshi S, Kaneko H, Bundo M, Iwamoto K, Yabe H.
    DNA methylation of ANKK1 and response to aripiprazole in patients with acute schizophrenia: A preliminary study.
    Journal of Psychiatric Research, 100:84-87, 2018

  17. Sugawara H, Murata Y, Ikegame T, Sawamura R, Shimanaga S, Takeoka Y, Saito T, Ikeda M, Yoshikawa A, Nishimura F, Kawamura Y, Kakiuchi C, Sasaki T, Iwata N, Hashimoto M, Kasai K, Kato T, Bundo M*, Iwamoto K*.
    DNA methylation analyses of the candidate genes identified by a methylome-wide association study revealed common epigenetic alterations in schizophrenia and bipolar disorder.
    Psychiatry and Clinical Neurosciences, in press

  18. Shimada-Sugimoto M, Otowa T*, Miyagawa T, Umekage T, Kawamura Y, Bundo M, Iwamoto K, Ikegame T, Tochigi M, Kasai K, Kaiya H, Tanii H, Okazaki Y, Tokunaga K, Sasaki T.
    An epigenome-wide methylation study of healthy individuals with or without depressive symptoms.
    Journal of Human Genetics​, in press

  19. Nishioka M, Bundo M, Ueda J, Katsuoka F, Sato Y, Kuroki Y, Ishii T, Ukai W, Murayama S, Hashimoto E, Nagasaki M, Yasuda J, Kasai K, Kato T, Iwamoto K.
    Identification of somatic mutations in postmortem human brains by whole genome sequencing and their implications for psychiatric disorders.
    Psychiatry and Clinical Neurosciences, in press

  20. Yoshikawa A, Nishimura F, Inai, A, Eriguchi, Y, Nishioka, M, Takaya A, Tochigi M, Kawamura Y, Umekage T, Kato K, Sasaki T, Ohashi Y, Iwamoto K, Kasai K, Kakiuchi C.
    Mutations of the glycine cleavage system genes possibly affect the negative symptoms of schizophrenia through metabolomic profile changes.
    Psychiatry and Clinical Neurosciences, in press

  21. Murata Y, Bundo M, Ueda J, Kubota-Sakashita M, Kasai K, Kato T, Iwamoto K.
    DNA methylation and hydroxymethylation analyses of the active LINE-1 subfamilies in mice.
    Scientific Reports, 7,13624, 2017

  22. Maekawa M, Watanabe A, Iwayama Y, Kimura T, Hamazaki K, Balan S, Ohba H, Hisano Y, Nozaki Y, Ohnishi T, Toyoshima M, Shimamoto C, Iwamoto K, Bundo M, Osumi N, Takahashi E, Takashima A, Yoshikawa T.
    Polyunsaturated fatty acid deficiency during neurodevelopment in mice models the prodromal state of schizophrenia through epigenetic changes in nuclear receptor genes.
    Translational Psychiatry, 7, e1229, 2017

  23. Ueda J†, Murata Y†, Bundo M, Oh-Nishi A, Kassai H, Ikegame T, Zhao Z, Jinde S, Aiba A, Suhara T, Kasai K, Kato T, Iwamoto K.
    Use of human methylation arrays for epigenome research in the common marmoset (Callithrix jacchus).
    Neuroscience Research, 120:60-65, 2017

  24. Shimada-Sugimoto M, Otowa T, Miyagawa T, Umekage T, Kawamura Y, Bundo M, Iwamoto K, Tochigi M, Kasai K, Kaiya H, Tanii H, Okazaki Y, Tokunaga K, Sasaki T.
    Epigenome-wide association study of DNA methylation in panic disorder.
    Clinical Epigenetics, 9:6, 2017

  25. Kasahara T, Ishiwata M, Kakiuchi C, Fuke S, Iwata N, Ozaki N, Kunugi H, Minabe Y, Nakamura K, Iwata Y, Fujii K, Kanba S, Ujike H, Kusumi I, Kataoka M, Matoba N, Takata A, Iwamoto K, Yoshikawa T, Kato T.
    Enrichment of deleterious variants of mitochondrial DNA polymerase gene (POLG1) in bipolar disorder.
    Psychiatry and Clinical Neurosciences, 71:518-529, 2017

  26. Sugawara H, Bundo M, Asai T, Sunaga F, Ueda J, Ishigooka J, Kasai K, Kato T, Iwamoto K*.
    Effects of quetiapine on DNA methylation in neuroblastoma cells.
    Progress in Neuro-Psychopharmacology and Biological Psychiatry 2014,56C:117-121.

  27. Koike S, Bundo M, Iwamoto K, Suga M, Kuwabara H, Ohashi Y, Shinoda K, Takano Y, Iwashiro N, Satomura Y, Nagai T, Natsubori T, Tada M, Yamasue H, Kasai K*.
    A snapshot of plasma metabolites in first-episode schizophrenia: A capillary electrophoresis time-of-flight mass spectrometry study.
    Translational Psychiatry 2014,4:e379

  28. Murata Y, Nishioka M, Bundo M, Sunaga F, Kasai K, Iwamoto K*. Comprehensive DNA methylation analysis of human neuroblastoma cells treated with blonanserin.
    Neuroscience Letters 2014,563:123-128.

  29. Kubota-Sakashita M†, Iwamoto K†, Bundo M, Kato T*.
    A role of ADAR2 and RNA editing of glutamate receptors in mood disorders and schizophrenia.
    Molecular Brain 2014,7:5.

  30. Bundo M, Toyoshima M, Okada Y, Akamatsu W, Ueda J, Nemoto-Miyauchi T, Sunaga F, Toritsuka M, Ikawa D, Kakita A, Kato M, Kasai K, Kishimoto T, Nawa H, Okano H, Yoshikawa T, Kato T*, Iwamoto K*.
    Increased L1 retrotransposition in the neuronal genome in schizophrenia.
    Neuron 2014,81:306-313.

  31. Mehta D, Iwamoto K, Ueda J, Bundo M, Adati N, Kojima T, Kato T*.
    Comprehensive survey of CNVs influencing gene expression in the human brain and its implications for pathophysiology.
    Neuroscience Research 2014,79:22-33.

  32. Iwata A*, Nagata K, Hatsuta H, Takuma H, Bundo M, Iwamoto K, Tamaoka K, Murayama S, Saido T, Tsuji S.
    Altered CpG methylation in sporadic Alzheimer's disease is associated with APP and MAPT dysregulation.
    Human Molecular Genetics 2014,23:648-656.

  33. Ikegame T†, Bundo M†, Sunaga F, Asai T, Nishimura F, Yoshikawa A, Kawamura Y, Hibino H, Tochigi M, Kakiuchi C, Sasaki T, Kato T, Kasai K, Iwamoto K*.
    DNA methylation analysis of BDNF gene promoters in peripheral blood cells of schizophrenia patients.
    Neuroscience Research 2013,77:208-214.

  34. Asai T†, Bundo M†, Sugawara H, Sunaga F, Ueda J, Tanaka G, Ishigooka J, Kasai K, Kato T, Iwamoto K*.
    Effect of mood stabilizers on DNA methylation in human neuroblastoma cells.
    International Journal of Neuropsychopharmacology 2013,16:2285-2294.

  35. Nishioka M, Shimada T, Bundo M, Ukai W, Hashimoto E, Saito T, Kano Y, Sasaki T, Kasai K, Kato T*, Iwamoto K*.
    Neuronal cell-type specific DNA methylation patterns of the Cacna1c gene.
    International Journal of Developmental Neuroscience 2013,31:89-95.

  36. Nishioka M, Bundo M, Koike S, Takizawa R, Kakiuchi C, Araki T, Kasai K, Iwamoto K*.
    Comprehensive DNA methylation analysis of peripheral blood cells derived from patients with first-episode schizophrenia.
    Journal of Human Genetics 2013,58:91-97.

  37. Bundo M, Sunaga F, Ueda J, Kasai K, Kato T, Iwamoto K*.
    A systematic evaluation of whole genome amplification of bisulfite-modified DNA.
    Clinical Epigenetics 2012,4:22.

  38. Yu CC, Furukawa M, Kobayashi K, Shikishima C, Cha PC, Sese J, Sugawara H, Iwamoto K, Kato T, Ando J, Toda T.
    Genome-wide DNA methylation and gene expression analyses of monozygotic twins discordant for intelligence levels.
    PLoS One 2012,7:e47081

  39. Kato T*, Hayashi-Takagi A, Toyota T, Yoshikawa T, Iwamoto K*.
    Gene expression analysis in lymphoblastoid cells as a potential biomarker of bipolar disorder.
    Journal of Hum Genetics 2011,56:779-783.

  40. Sugawara H, Iwamoto K, Bundo M, Ueda J, Miyauchi T, Komori A, Kazuno AA, Adati N, Kusumi I, Okazaki Y, Ishigooka J, Kojima T, Kato T*. Hypermethylation of serotonin transporter gene in bipolar disorder detected by epigenome analysis of discordant monozygotic twins. Translational Psychiatry 2011,1:e24.

  41. Yamada K, Iwayama Y, Hattori E, Iwamoto K, Toyota T, Ohnishi T, Ohba H, Maekawa M, Kato T, Yoshikawa T*.
    Genome-wide association study of schizophrenia in Japanese population.
    PLoS One 2011,6:e20468.

  42. Iwamoto K†*, Bundo M†, Ueda J, Oldham MC, Ukai W, Hashimoto E, Saito T, Geschwind DH, Kato T*.
    Neurons show distinctive DNA methylation profile and higher interindividual variations compared with non-neurons.
    Genome Research 2011,21:688-696.

  43. Iwamoto K*, Ueda J, Bundo M, Kojima T, Kato T*.
    Survey of the effect of genetic variations on gene expression in human prefrontal cortex and its application to genetics of psychiatric disorders.
    Neuroscience Research 2011,70:238-242.

  44. Sugawara H, Iwamoto K, Bundo M, Ueda J, Ishigooka J, Kato T*.
    Comprehensive DNA methylation analysis of human peripheral blood leukocytes and lymphoblastoid cell lines.
    Epigenetics 2011,6:508-515.

  45. Kubota M, Kasahara T, Iwamoto K, Komori A, Miyauchi T, Ishiwata M, Kato T*.
    Therapeutic implications of down-regulation of cyclophilin D in bipolar disorder.
    International Journal of Neuropsychopharmacology 2010,13:1355-1368.

  46. Sugawara H, Iwamoto K, Bundo M, Ishiwata M, Ueda J, Kakiuchi C, Ishigooka J, Kato T*.
    Effect of mood stabilizers on gene expression in lymphoblastoid cells.
    Journal of Neural Transmission 2010,117:155-164.

  47. Iwayama Y, Hattori E, Maekawa M, Yamada K, Toyota T, Ohnishi T, Iwata Y, Tsuchiya KJ, Sugihara G, Kikuchi M, Hashimoto K, Iyo M, Inada T, Kunugi H, Ozaki N, Iwata N, Nanko S, Iwamoto K, Okazaki Y, Kato T, Yoshikawa T*.
    Association analyses between brain-expressed fatty-acid binding protein (FABP) genes and schizophrenia and bipolar disorder.
    American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 2010,153B:484-493.

  48. Bundo M, Iwamoto K, Yamada K, Yoshikawa T, Kato T*.
    Mutation screening and assessment of the effect of genetic variations on expression and RNA editing of serotonin receptor 2C in the human brain.
    Psychiatry and Clinical Neurosciences 2010,64:57-61.

  49. Washizuka S, Iwamoto K, Kakiuchi C, Bundo M, Kato T*.
    Expression of mitochondrial complex I subunit gene NDUFV2 in the lymphoblastoid cells derived from patients with bipolar disorder and schizophrenia.
    Neuroscience Research 2009,63:199-204.

  50. Sugawara H, Iwamoto K, Bundo M, Kazuno AA, Nakano Y, Ishigooka J, Kato T*.
    A 3-bp deletion of mitochondrial DNA tRNALys observed in lymphoblastoid cells.
    Journal of Human Genetics 2009,54:612-613.

  51. Nakatani J, Tamada K, Hatanaka F, Ise S, Ohta H, Inoue K, Tomonaga S, Watanabe Y, Chung YJ, Banerjee R, Iwamoto K, Kato T, Okazawa M, Yamauchi K, Tanda K, Takao K, Miyakawa T, Bradley A, Takumi T*.
    Abnormal behavior in a chromosome-engineered mouse model for human 15q11-13 duplication seen in autism.
    Cell 2009,137:1235-1246.

  52. Tochigi M, Iwamoto K, Bundo M, Sasaki T, Kato N, Kato T*.
    Gene expression profiling of major depression and suicide in the prefrontal cortex of postmortem brains.
    Neuroscience Research 2008,60:184-191.

  53. Tochigi M, Iwamoto K, Bundo M, Komori A, Sasaki T, Kato N, Kato T*.
    Methylation status of the reelin promoter region in the brain of schizophrenic patients.
    Biological Psychiatry 2008,63:530-533.

  54. Oldham MC*, Konopka G, Iwamoto K, Langfelder P, Kato T, Horvath S, Geschwind DH*.
    Functional organization of the transcriptome in human brain.
    Nature Neuroscience 2008,11:1271-1282.

  55. Kuratomi G, Iwamoto K, Bundo M, Kusumi I, Kato N, Iwata N, Ozaki N, Kato T*.
    Aberrant DNA methylation associated with bipolar disorder identified from discordant monozygotic twins.
    Molecular Psychiatry 2008,13:429-441.

  56. Kato T, Ishiwata M, Yamada K, Kasahara T, Kakiuchi C, Iwamoto K, Kawamura K, Ishihara H, Oka Y*.
    Behavioral and gene expression analyses of Wfs1 knockout mice as a possible animal model of mood disorder.
    Neuroscience Research 2008,61:143-158.

  57. Iwamoto K*, Ueda J, Bundo M, Nakano Y, Kato T.
    Effect of a functional single nucleotide polymorphism in the 2',3'-cyclic nucleotide 3'-phosphodiesterase gene on the expression of oligodendrocyte-related genes in schizophrenia.
    Psychiatry and Clinical Neurosciences 2008,62:103-108.

  58. Nakatani N, Ohnishi T, Iwamoto K, Watanabe A, Iwayama Y, Yamashita S, Ishitsuka Y, Moriyama K, Nakajima M, Tatebayashi Y, Akiyama H, Higuchi T, Kato T, Yoshikawa T*.
    Expression analysis of actin-related genes as an underlying mechanism for mood disorders.
    Biochemical and Biophysical Research Communications 2007,352:780-786.

  59. Iwamoto K, Ueda J, Nakano Y, Bundo M, Ukai W, Hashimoto E, Saito T, Kato T*.
    Evaluation of whole genome amplification methods using postmortem brain samples.
    Journal of Neuroscience Methods 2007,165:104-110.

  60. Iwamoto K*, Bundo M, Ueda J, Nakano Y, Ukai W, Hashimoto E, Saito T, Kato T.
    Detection of chromosomal structural alterations in single cells by SNP arrays: a systematic survey of amplification bias and optimized workflow.
    PLoS One 2007,2:e1306.

  61. Hayashi A, Kasahara T, Iwamoto K, Ishiwata M, Kametani M, Kakiuchi C, Furuichi T, Kato T*.
    The role of brain-derived neurotrophic factor (BDNF)-induced XBP1 splicing during brain development.
    Journal of Biological Chemistry 2007,282:34525-34534.

  62. Kohda K*, Jinde S, Iwamoto K, Bundo M, Kato N, Kato T.
    Maternal separation stress drastically decreases expression of transthyretin in the brains of adult rat offspring.
    International Journal of Neuropsychopharmacology 2006,9:201-208.

  63. Iwamoto K, Bundo M, Yamada K, Takao H, Iwayama Y, Yoshikawa T, Kato T*.
    A family-based and case-control association study of SOX10 in schizophrenia.
    American Journal of Medical Genetics PartB: Neuropsychiatric Genetics 2006,141B:477-481.

  64. Iwamoto K*, Bundo M, Ueda J, Kato T.
    Expression of ribosomal subunit genes increased coordinately with postmortem interval in human brain.
    Molecular Psychiatry 2006,11:1067-1069.

  65. Munakata K, Iwamoto K, Bundo M, Kato T*.
    Mitochondrial DNA 3243A/G mutation and increased expression of LARS2 gene in the brains of patients with bipolar disorder and schizophrenia.
    Biological Psychiatry 2005,57:525-532.

  66. Kato T*, Iwayama Y, Kakiuchi C, Iwamoto K, Yamada K, Minabe Y, Nakamura K, Mori N, Fujii K, Nanko S, Yoshikawa T.
    Gene expression and association analyses of LIM (PDLIM5) in bipolar disorder and schizophrenia.
    Molecular Psychiatry 2005,10:1045-1055.

  67. Kakiuchi C*, Ishiwata M, Kametani M, Nelson C, Iwamoto K, Kato T.
    Quantitative analysis of mitochondrial DNA deletions in the brains of patients with bipolar disorder and schizophrenia.
    International Journal of Neuropsychopharmacology 2005,8:515-522.

  68. Iwamoto K*, Nakatani N, Bundo M, Yoshikawa T, Kato T.
    Altered RNA editing of serotonin 2C receptor in a rat model of depression.
    Neuroscience Research 2005,53:69-76.

  69. Iwamoto K*, Bundo M, Yamada K, Takao H, Iwayama-Shigeno Y, Yoshikawa T, Kato T.
    DNA methylation status of SOX10 correlates with its downregulation and oligodendrocyte dysfunction in schizophrenia.
    Journal of Neuroscience 2005,25:5376-5381.

  70. Iwamoto K†*, Bundo M†, Kato T.
    Estimating RNA editing efficiency of five editing sites in the serotonin 2C receptor by pyrosequencing.
    RNA 2005,11:1596-1603.

  71. Iwamoto K, Bundo M, Kato T*.
    Altered expression of mitochondria-related genes in postmortem brains of patients with bipolar disorder or schizophrenia, as revealed by large-scale DNA microarray analysis.
    Human Molecular Genetics 2005,14:241-253.

  72. Huang YT, Iwamoto K, Kurosaki T, Nasu M, Ueda S*.
    The neuronal POU transcription factor Brn-2 interacts with Jab1, a gene involved in the onset of neurodegenerative diseases.
    Neuroscience Letters 2005,382:175-178.

  73. Aoki-Suzuki M, Yamada K, Meerabux J, Iwayama-Shigeno Y, Ohba H, Iwamoto K, Takao H, Toyota T, Suto Y, Nakatani N, Dean B, Nishimura S, Seki K, Kato T, Itohara S, Nishikawa T, Yoshikawa T*.
    A family-based association study and gene expression analyses of netrin-G1 and -G2 genes in schizophrenia.
    Biological Psychiatry 2005,57:382-393.

  74. Washizuka S, Iwamoto K, Kazuno AA, Kakiuchi C, Mori K, Kametani M, Yamada K, Kunugi H, Tajima O, Akiyama T, Nanko S, Yoshikawa T, Kato T*.
    Association of mitochondrial complex I subunit gene NDUFV2 at 18p11 with bipolar disorder in Japanese and the National Institute of Mental Health pedigrees.
    Biological Psychiatry 2004,56:483-489.

  75. Iwamoto K, Kakiuchi C, Bundo M, Ikeda K, Kato T*.
    Molecular characterization of bipolar disorder by comparing gene expression profiles of postmortem brains of major mental disorders.
    Molecular Psychiatry 2004,9:406-416.

  76. Iwamoto K, Bundo M, Yamamoto M, Ozawa H, Saito T, Kato T*.
    Decreased expression of NEFH and PCP4/PEP19 in the prefrontal cortex of alcoholics.
    Neuroscience Research 2004,49:379-385.

  77. Iwamoto K, Bundo M, Washizuka S, Kakiuchi C, Kato T*.
    Expression of HSPF1 and LIM in the lymphoblastoid cells derived from patients with bipolar disorder and schizophrenia.
    Journal of Human Genetics 2004,49:227-231.

  78. Ide M, Muratake T, Yamada K, Iwayama-Shigeno Y, Iwamoto K, Takao H, Toyota T, Kaneko N, Minabe Y, Nakamura K, Kato T, Mori N, Asada T, Someya T, Yoshikawa T*.
    Genetic and expression analyses of FZD3 in schizophrenia.
    Biological Psychiatry 2004, 56:462-465.

  79. Kato T*, Iwamoto K, Washizuka S, Mori K, Tajima O, Akiyama T, Nanko S, Kunugi H, Kato N.
    No association of mutations and mRNA expression of WFS1/wolframin with bipolar disorder in humans.
    Neuroscience Letters 2003,338:21-24.

  80. Kakiuchi C, Iwamoto K, Ishiwata M, Bundo M, Kasahara T, Kusumi I, Tsujita T, Okazaki Y, Nanko S, Kunugi H, Sasaki T, Kato T*.
    Impaired feedback regulation of XBP1 as a genetic risk factor for bipolar disorder.
    Nature Genetics 2003,35:171-175.

  81. Iwamoto K, Kato T*.
    RNA editing of serotonin 2C receptor in human postmortem brains of major mental disorders.
    Neuroscience Letters 2003,346:169-172.

  82. Iwamoto K, Kato T*.
    Effects of cocaine and reserpine administration on RNA editing of rat 5-HT2C receptor estimated by primer extension combined with denaturing high-performance liquid chromatography.
    Pharmacogenomics Journal 2002,2:335-340.

  83. Iwamoto K, Huang Y, Ueda S*.
    Genomic organization and alternative transcripts of the human PQBP-1 gene.
    Gene 259:69-73, 2000
     

 

　英文総説など　

  1. Nishioka M, Bundo M, Iwamoto K*, Kato T*.
    Somatic mutations in the human brain: implications for psychiatric research.
    Molecular Psychiatry, 24:839-856, 2019

  2. Iwamoto K*.
    Understanding the epigenetic architecture of psychiatric disorders: modifications and beyond.
    Psychiatry and Clinical Neurosciences, 72:194, 2018

  3. Bundo M*, Kato T, Iwamoto K.
    Estimation of LINE-1 Copy Number in the Brain Tissue and Isolated Neuronal Nuclei.
    In: Frade J., Gage F. (eds) Genomic Mosaicism in Neurons and Other Cell Types. Neuromethods, 2017 vol 131. Humana Press, New York, NY

  4. Bundo M*, Kato T, Iwamoto K.
    Cell Type-Specific DNA Methylation Analysis in Neurons and Glia.
    In: Karpova N. (eds) Epigenetic Methods in Neuroscience Research. Neuromethods, 2016 vol 105. Humana Press, New York, NY

  5. Kato T*, Iwamoto K.
    Comprehensive DNA methylation and hydroxymethylation analysis in the human brain and its implication in mental disorders.
    Neuropharmacology 2014,80C:133-139.

  6. Hayashi-Takagi A*, Vawter MP, Iwamoto K.
    Peripheral biomarkers revisited:　integrative profiling of peripheral samples for psychiatric research.
    Biological Psychiatry 2014,75:920-928.

  7. Ikegame T, Bundo M, Murata Y, Kasai K, Kato T, Iwamoto K*.
    DNA methylation of the BDNF gene and its relevance to psychiatric disorders.
    Journal of Human Genetics 2013,58:434-438.

  8. Sugawara H, Bundo M, Ishigooka J, Iwamoto K, Kato T*.
    Epigenetic regulation of serotonin transporter in psychiatric disorders.
    Journal of Genetics and Genomics 2013,40:325-329.

  9. Nishioka M, Bundo M, Kasai K, Iwamoto K*.
    DNA methylation in schizophrenia: progress and challenges of epigenetic studies.
    Genome Medicine 2012,4:96.

  10. Iwamoto K*, Bundo M, Kasai K, Kato T.
    Measuring RNA editing of serotonin 2C receptor.
    Biochemistry (Moscow) 2011,76:912-914.

  11. Iwamoto K*, Bundo M, Kato T.
    (book chapter) RNA editing of serotonin 2C receptor and neuropsychiatric diseases.
    5-HT2C receptors in the pathophysiology of CNS disease, Springer, Berlin 2010,157-167.

  12. Iwamoto K*, Kato T.
    Epigenetic profiling in schizophrenia and major mental disorders.
    Neuropsychobiology 2009,60:5-11.

  13. Iwamoto K*, Bundo M, Kato T.
    Serotonin receptor 2C and mental disorders: genetic, expression and RNA editing studies.
    RNA Biology 2009,6:248-253.

  14. Kato T*, Kakiuchi C, Iwamoto K.
    Comprehensive gene expression analysis in bipolar disorder.
    Canadian Journal of Psychiatry 2007,52:763-771.

  15. Iwamoto K*, Kato T.
    Gene expression profiling in schizophrenia and related mental disorders.
    Neuroscientist 2006,12:349-361.

  16. Kato T*, Iwamoto K, Kakiuchi C, Kuratomi G, Okazaki Y.
    Genetic or epigenetic difference causing discordance between monozygotic twins as a clue to molecular basis of mental disorders.
    Molecular Psychiatry 2005,10:622-630.
     

 

　邦文総説　

  1. 文東美紀、清田恵美、岩本和也、精神疾患患者試料を使用した1細胞研究の現在、医学のあゆみ (医歯薬出版、2021,276:1022-1026)

  2. 藤飯愼也、岩本和也、トランスポゾンはアンチエイジングのターゲットとなるか？ アンチエイジング医学 (メディカルレビュー社、2020,16:396-398)

  3. 文東美紀、岩本和也、 レトロトランスポゾンが引き起こすヒト疾患 、医学のあゆみ (医歯薬出版、2020,273: 1129-1132)

  4. 岩本和也、池亀天平、文東美紀、精神疾患とエピジェネティクス : セロトニントランスポーターの大規模DNAメチル化解析からの考察、医学のあゆみ  (医歯薬出版、2020, 272:1212-1215)

  5. 渡邊理紗、岩本和也、精神疾患とepigenetic age、医学のあゆみ（医歯薬出版、2020, 272:57-60)

  6. ​岩本和也、文東美紀、体細胞変異と精神疾患、精神科（科学評論社、2019, 35:375-378)

  7. 村田唯、文東美紀、岩本和也、精神疾患におけるエピゲノムとレトロトランスポゾン研究、ストレス科学 (日本ストレス学会、2019,34:12-19)

  8. 松原ひかり、村田唯、文東美紀、岩本和也、統合失調症と妊娠期ウイルス感染、精神科治療学（星和書店、2019, 34:1013-1015)

  9. 黒木遼太、文東美紀、岩本和也、【精神科領域用語解説】メチローム解析、分子精神医学（先端医学社、2019, 19:154-155)

  10. 菅原裕子、村田唯、池亀天平、嶋永翔太、竹岡優将、齋藤竹生、池田匡志、吉川茜、西村文親、河村代志也、垣内千尋、佐々木司、岩田仲生、橋本衛、笠井清登、加藤忠史、文東美紀、岩本和也、統合失調症と双極性障害における共通のDNAメチル化変化、精神神経学雑誌（2019、121：251-258)

  11. 文東美紀、岩本和也、ヒト死後脳のさまざまな細胞種におけるゲノム・エピゲノム研究、「バイオイノベーションに向けて」(シーエムシー出版 2019, p223-229)

  12. ​岩本和也、精神医学研究における非医師および女性研究者の参画状況について、精神神経学雑誌（2018、120：1027-1031)

  13. 澤村理英、文東美紀、岩本和也、統合失調症とエピジェネティクス、精神科「統合失調症の研究最前線」（科学評論社、2018 32 (3):189-193)

  14. 池亀天平、笠井清登、岩本和也、精神疾患におけるエピゲノム研究、CLINICAL NEUROSCIENCE 「ニューロジェネティクス新時代」(中外医学社、2018 36,2, 253-255)

  15. 菅原裕子、橋本衛、岩本和也、うつ病、CLINICAL NEUROSCIENCE 「ニューロジェネティクス新時代」(中外医学社、2018 36,2, 249-252)

  16. Watanabe R, Nishioka M, Bundo M, Sawai Y, Ueda J, Murata Y, Ishii T, Ukai W, Hashimoto E, Kasai K, Simizu S, Kato T, Iwamoto K. Epigenetic status of LINE-1 promoters in neurons and non-neurons. 日本神経精神薬理学雑誌(2017 37:83-84)

  17. 菅原裕子、文東美紀、池亀天平、近藤健治、池田匡志、岩田仲生、石郷岡純、笠井清登、加藤忠史、岩本和也　統合失調症と双極性障害における共通ならびに特有のエピジェネティック要因についての検討　日本神経精神薬理学雑誌 (2017 37:81)

  18. 菅原裕子、日高洋介、文東美紀、岩本和也　精神ストレスとエピゲノム応答　最新医学 (2017 72,5, p733-739)

  19. 渡邊理紗、岩本和也　精神疾患とエピジェネティクス―大うつ病、双極性障害、統合失調症の一卵性双生児不一致例におけるDNAメチル化研究、別冊医学のあゆみ「クリニカルエピゲノミクス」 (医歯薬出版、2016、p99-102, 医学のあゆみ 255: 673-676の再掲)

  20. 西岡将基、文東美紀、笠井清登、岩本和也　次世代シークエンサーを用いた脳ゲノム解析　分子精神医学（先端医学社、2016 16:180-185）

  21. 村田唯、文東美紀、笠井清登、岩本和也　統合失調症におけるエピゲノム異常～患者由来脳組織および末梢組織を用いた最新研究、実験医学増刊「エピゲノム研究～修飾の全体像の理解から先制・個別化医療へ」(羊土社、2016、p140-144)

  22. 渡邊理紗、岩本和也　精神疾患とエピジェネティクス―大うつ病、双極性障害、統合失調症の一卵性双生児不一致例におけるDNAメチル化研究、医学のあゆみ 2015, 255:673-676

  23. 緒方優、池亀天平、文東美紀、笠井清登、岩本和也　セロトニントランスポーターのDNAメチル化と精神疾患、日本生物学的精神医学会誌 2015, 26:3-6

  24. 池亀天平、文東美紀、笠井清登、岩本和也　精神疾患におけるエピゲノム研究、分子精神医学 2015,15:87-94

  25. 菅原裕子、文東美紀、石郷岡純、加藤忠史、岩本和也　精神疾患とエピジェネティクス、生体の科学 2014,65:595-600

  26. 村田唯、文東美紀、笠井清登 岩本和也　精神疾患とエピジェネティクス―治療薬の作用機序の観点から、臨床精神薬理 2014,17:1663-1666

  27. 文東美紀、加藤忠史、岩本和也　統合失調症の患者死後脳ではLINE-1配列が増加している、科学 2014,84:808-810

  28. 岩本和也　統合失調症の発症メカニズムと環境要因：エピゲノム研究からの理解、環境ホルモンニュースレター 2014,17:6

  29. 池亀天平、文東美紀、笠井清登、岩本和也　第4編第8章　精神疾患におけるエピジェネティクス解析、エピジェネティクスの産業応用 畑田出穂、久保田健夫監修 シーエムシー出版 2014:p232-238

  30. 文東美紀、加藤忠史、岩本和也　統合失調症の神経細胞ゲノムではLINE-1のコピー数が増加している、実験医学 2014,32:1257-1260

  31. 文東美紀、加藤忠史、岩本和也　LINE-1、分子精神医学 2014,14:138-139

  32. 池亀天平、文東美紀、笠井清登、岩本和也　統合失調症におけるエピジェネティクス解析、生体の科学 2014,65:55-59

  33. 岩本和也、文東美紀、加藤忠史　第15章 「精神疾患のエピジェネティクス」 エピジェネティクス―その分子機構から高次生命機能まで 田嶋正二／編 化学同人 2013

  34. 村田唯、文東美紀、岩本和也　第3部第7章 「精神疾患」 イラストで徹底理解するエピジェネティクスキーワード事典―分子機構から疾患・解析技術まで 牛島俊和，眞貝洋一／編 羊土社 2013:p215-219

  35. 岩本和也　脳ゲノム解析―配列と修飾の多型性に基づく精神疾患の病態解析―、分子精神医学　2013,13:226-227

  36. 池亀天平、岩本和也　第15章: 死後脳研究、統合失調症 日本統合失調症学会監修、福田正人、糸川昌成、村井俊哉、笠井清登編集、医学書院 2013,p197-201

  37. 村田唯、文東美紀、岩本和也　エピジェネティクス、脳科学辞典

  38. 西岡将基、文東美紀、笠井清登、岩本和也　統合失調症におけるエピジェネティクス研究の現状と課題、日本臨床2013,71:605-609.

  39. 岩本和也、文東美紀、笠井清登、加藤忠史、気分障害におけるエピゲノム解析、気分障害の薬理・生化学～うつ病の脳内メカニズム研究：進歩と挑戦 躁うつ病の薬理・生化学的研究懇話会編、医薬ジャーナル社 2012,6:287-292

  40. 文東美紀、笠井清登、加藤忠史、岩本和也　脳ゲノム多様性と精神疾患、日本生物学的精神医学会誌 2012,23:29-33.

  41. 岩本和也、笠井清登　言語障害と分子遺伝学から考える言語進化、進化言語学の構築―新しい人間科学を目指して　藤田耕司&岡ノ谷一夫編、ひつじ書房 2012,3:161-170.

  42. 浅井竜朗、文東美紀、笠井清登、岩本和也　精神疾患のエピジェネティクス、チャイルドヘルス 2012,15:182-184.

  43. 笠井清登、吉川茜、夏堀龍暢、小池進介、永井達哉、荒木剛、西村幸香、岩本和也　統合失調症の生物学的研究、BRAIN and NERVE 2012,64:109-118.

  44. 西岡将基、文東美紀、笠井清登、岩本和也　統合失調症のエピジェネティクス、精神科治療学 2011,26:1371-1377.

  45. 荒木剛、岩本和也、笠井清登　統合失調症と脳―発達か変性か？ 脳バンク―精神疾患の謎を解くために 加藤忠史&ブレインバンク委員会編、光文社 2011,5:194-200.

  46. 岩本和也、文東美紀　DNAメチル化研究の最新の動向、分子精神医学 2011,11:90-93.

  47. 加藤忠史、文東美紀、岩本和也　神経細胞のDNAメチル化、分子精神医学 2011,11:112-117.

  48. 文東美紀、岩本和也、加藤忠史　セロトニン2C受容体、生体の科学 2010,61:394-396.

  49. 文東美紀、岩本和也　気分障害患者の死後脳におけるオミックス研究、Medical Bio2010,48:46-51.

  50. 岩本和也、加藤忠史　脳神経系ゲノムの多型性と精神疾患、脳と精神の医学2009,20:331-337.

  51. 岩本和也、加藤忠史　双極性障害のゲノムワイド研究、医学のあゆみ 2009,231:1019-1022.

  52. 岩本和也、加藤忠史　ゲノム多型の遺伝子発現への影響評価と精神疾患研究、医学のあゆみ 2009,229:199-201.

  53. 加藤忠史、岩本和也　精神疾患とepigenetics、細胞工学　2009,28:567-571.

  54. 文東美紀、岩本和也、加藤忠史　精神疾患におけるPyrosequencingの利用、エピジェネティクス関連Protocol 羊土社 2008

  55. 岩本和也、加藤忠史　セロトニン2C受容体のRNA編集と精神疾患、薬学雑誌2008,128:521-525.

  56. 岩本和也　オリゴデンドロサイト関連遺伝子、KEY WORD精神第4版 先端医学社2007,152-153.

  57. 岩本和也、加藤忠史　ヒト死後脳を用いた遺伝子発現解析における交絡因子の影響解析と実際的な研究ストラテジーの検討、精神薬療研究年報 2007,39:177-184.

  58. 岩本和也　精神疾患に対するepigenetics的アプローチの可能性、Psychiatry Today 2007,13:19-20.

  59. 岩本和也、加藤忠史　気分障害患者死後脳を用いたDNAマイクロアレイ研究、分子精神医学 2006,17:257-263.

  60. 加藤忠史、岩本和也　エピジェネティクス、分子精神医学 2006,6:72-74.

  61. 加藤忠史、岩本和也 精神疾患とRNA編集、医学のあゆみ 2005,215:679-682.

  62. 岩本和也、加藤忠史 精神疾患とエピジェネティクス―統合失調症と双極性障害におけるDNAメチル化研究に関する最近の話題、脳と精神の医学 2005,16:81-86

  63. 加藤忠史、岩本和也 精神疾患とエピジェネティクス、医学のあゆみ 2005,215:137-140.

  64. 加藤忠史、岩本和也 精神疾患における遺伝子発現の研究－DNAからRNAへ、精神神経学雑誌 2004,106:49-52.

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